Systemic effects of intratympanic dexamethasone therapy

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چکیده

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Systemic effects of intratympanic dexamethasone therapy

OBJECTIVE The study aimed to assess the possible systemic effects of intratympanic dexamethasone (IT-Dex) on the hypothalamic-pituitary-adrenal (HPA) axis, inflammation, and bone metabolism. DESIGN A prospective cohort study including 30 adult patients of a tertiary referral ENT clinic treated with 9.6 mg IT-Dex over a period of 10 days was carried out. METHODS Effects on plasma and salivar...

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Intratympanic dexamethasone for sudden sensorineural hearing loss after failure of systemic therapy.

OBJECTIVE Intratympanic steroids are increasingly used in the treatment of inner ear disorders, especially in patients with sudden sensorineural hearing loss (SNHL) who have failed systemic therapy. We reviewed our experience with intratympanic steroids in the treatment of patients with sudden SNHL to determine overall success, morbidity, and prognostic factors. HYPOTHESIS Intratympanic stero...

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Combined Intratympanic and Systemic Steroid Therapy for Poor-Prognosis Sudden Sensorineural Hearing Loss

Introduction: The aim of this study was to evaluate the efficacy of combined intratympanic and systemic steroid therapy compared with systemic steroid therapy alone in idiopathic sudden sensorineural hearing loss (ISSNHL) patients with poor prognostic factors.     Materials and Methods: Seventy-seven patients with sudden sensorineural hearing loss (SSNHL) who had at least one poor prognostic fa...

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Systemic sclerosis and dexamethasone cyclophosphamide pulse therapy.

Sir, There have been quite a few instances where the physician or may be even a dermatologist (mis) advices a patient having systemic sclerosis that there is no satisfactory treatment for this disease, as has also been done in the paper ‘Therapeutic trials for systemic sclerosis: An update’ by Sardana and Garg.[1] Such patients often feel frustrated and disappointed, till another dermatologist ...

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ژورنال

عنوان ژورنال: Endocrine Connections

سال: 2014

ISSN: 2049-3614

DOI: 10.1530/ec-14-0076